ABSTRACT
Occupational exposure to diacetyl can lead to bronchiolitis obliterans. In this paper, two patients with severe obstructive ventilation disorder who were exposed to diacetyl at a fragrance and flavours factory were analyzed. The clinical manifestations were cough and shortness of breath. One of them showed Mosaic shadows and uneven perfusion in both lungs on CT, while the other was normal. Field investigation found that 4 of the 8 workers in the factory were found to have obstructive ventilation disorder, and 2 had small airway dysfunction. This paper summarizes the diagnostic process of patients in order to improve the understanding of airway dysfunction caused by occupational exposure to diacetyl and promote the development of relevant standards.
Subject(s)
Humans , Diacetyl/adverse effects , Occupational Diseases/diagnosis , Occupational Exposure/adverse effects , Lung , Bronchiolitis Obliterans/diagnosisABSTRACT
Objective To explore the effect of dexmedetomidine combined with sevoflurane on the postoperative sedation for children undergoing ophthalmic operation.Methods Pediatric patients (200 cases) in Ankang Hospital of Traditional Chinese Medicine from January 2014 to August 2016 were enrolled,of which patients were divided into two groups randomly,Group A (n =100) accepted sevoflurane combined with normal saline,and Group B (n =100) adopted sevoflurane combined with dexmedetomidine.The operative conditions and postoperative VAS,Ramsay and PEAD scores were evaluated,and the postoperative adverse reactions were recorded and analyzed.Results There was no significance of the operation time between two groups,the wakened time of Group B was later than that of Group A significantly (P ＜ 0.05),the postoperative extubation quality score of Group B was lower than that in Group A (P ＜ 0.05),and the times of using analgesic in Group B was fewer than that of Group A (P ＜ 0.05);The VAS score of patients in Group B was significantly lower than that of Group A at the time points of T1,T2 and T3;At the time points ofT1 and T2,the Ramsay score of patients in Group B was higher than that in Group A,and PAED score of Group B was lower than that in Group A,with significant difference between Groups A and B (P ＜ 0.05);The incidence of nausea and vomiting,respiratory depression,postoperative agitation of patients in Group B was lower significantly than that of Group A,and the incidence of total adverse reactions in Group B was also lower than that in Group A significantly (P ＜ 0.05).Conclusion The clinical efficacy and safety of dexmedetomidine combined with sevoflurane for patients undergoing ophthalmic operation are remarkable and deserve popularization in clinic,which not only relieves the restlessness agitation of patients in recovery period,but also decreases the incidence of adverse reactions.
ABSTRACT
<p><b>BACKGROUND</b>Our previous studies have shown that both apoptosis and necrosis are involved in hair cell (HC) pathogenesis in aging cochleae. To better understand the biological mechanisms responsible for the regulation of HC death, we examined the activity of succinate dehydrogenase (SDH), a mitochondrial bioenergetic enzyme, in the HCs of aging cochleae.</p><p><b>METHODS</b>The auditory brainstem response thresholds elicited by tone bursts at 4, 10 and 20 kHz were measured in both young (2-3 months) and aging (22-23 months) Wistar rats. SDH activity was evaluated with a colorimetric assay using nitroblue tetrazolium monosodium salt. The SDH-labeled organs of Corti were double stained with propidium iodide, a DNA intercalating fluorescent probe for illustration of HC nuclei. All the specimens were examined with fluorescence microscopy and confocal microscopy.</p><p><b>RESULTS</b>Aging rats exhibited a significant elevation of ABR thresholds with threshold shifts being 34 dB at 20 kHz, 28 dB at 10 kHz, and 25 dB at 4 kHz. Consistent with the reduction in the cochlear function, aging cochleae exhibited the reduction of SDH staining intensity in the apical and the basal ends of the cochleae, where a large number of apoptotic, necrotic, and missing HCs were evident. The reduction in SDH staining appeared in a cell-death-mode dependent fashion. Specifically, SDH labeling remained in apoptotic HCs. In contrast, SDH staining was markedly reduced or absent in necrotic HCs.</p><p><b>CONCLUSIONS</b>In the aging cochlea, SDH activity is preserved in HCs undergoing apoptosis, but is substantially reduced in necrosis. These results suggest that mitochondrial energetic function is involved in the regulation of cell death pathways in the pathogenesis of aging cochleae.</p>